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<B>Validation of Blood and CSF Pathologic Proteins with Neuropathology, Imaging
and CSF Findings </B>
   Lead Investigator:    Yan Li
   Institution      :    Washington University in St Louis
   E-Mail           :    yanli833@wustl.edu
   Proposal ID      :    1344
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>This project will validate key pathologic proteins that can now be highly         accurately measured in blood in addition to CSF.  Results will inform about the biological changes in the brain compared to blood and CSF and identify            pathologies and stages of AD. Individual participant results will be sent to       ADCs to open the possibilities of massive increases in data interpretation and findings.                                                                           Specific Aim 1: to determine the relationship of a panel of blood and CSF         phospho-tau isoforms to neuropathology, imaging and CSF biomarkers and clinical and cognitive assessments.                                                          Specific Aim 2: to determine the relationship of plasma and CSF amyloid-beta      isoforms to neuropathology, imaging and other CSF biomarkers and clinical and     cognitive assessments.                                                              Specific Aim 3: to quantify plasma ApoE isoforms in a multiplexed assay with amyloid-beta to improve diagnostic accuracy and measure amounts of the protein using 10 unique regions across the ApoE protein that are specific for production cell type. </textarea>